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Updated: May 9, 2026

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
High-intensity intermittent exercise attenuates ad-libitum energy intake.
A Y Sim1, K E Wallman1, T J Fairchild2
1School of Sport Science, Exercise and Health, The University of Western Australia, Perth, Western Australia, Australia.
High-intensity intermittent exercise significantly reduces subsequent energy intake in sedentary, overweight men. This exercise type was well-tolerated, suggesting its potential for weight management.
Area of Science:
- Exercise Physiology
- Nutritional Science
- Obesity Research
Background:
- Sedentary, overweight individuals often struggle with energy balance.
- Understanding the impact of exercise intensity on appetite regulation is crucial for weight management strategies.
Purpose of the Study:
- To investigate the acute effects of high-intensity intermittent exercise (HIIE) on energy intake.
- To assess changes in appetite perceptions and related hormones following HIIE in overweight men.
Main Methods:
- Seventeen overweight men underwent four conditions: resting control, moderate-intensity continuous exercise, HIIE, and very-high-intensity intermittent exercise.
- Energy intake was measured via a standardized meal and an ad-libitum meal, along with 38-hour free-living energy intake.
- Appetite perceptions, blood lactate, glucose, and active ghrelin levels were monitored.
Main Results:
- Very-high-intensity intermittent exercise (VHI) led to lower ad-libitum and subsequent free-living energy intake compared to control and moderate-intensity exercise.
- VHI was associated with lower active ghrelin and higher blood lactate and glucose levels.
- Despite higher exertion, enjoyment of physical activity was similar across exercise conditions.
Conclusions:
- High-intensity intermittent exercise effectively suppresses subsequent energy intake in overweight, inactive men.
- This exercise modality is well-tolerated in an overweight population, indicating its potential as a weight management tool.
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