[Allergy diagnostics in suspected metal implant intolerance]
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Updated: May 9, 2026

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
Published on: July 1, 2013
1Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland. Peter.Thomas@med.uni-muenchen.de
Abstract:
Allergy diagnostics may be requested before implantation or in cases of complications by implants. Preimplant allergy testing by patch test should only be done in patients with a reported history of potential allergies to metal or bone cement components and prophetic prophylactic testing should not be done. For baseline diagnostics of suspected implant allergy a patch test with the standard series (containing Ni, Co and Cr preparations) and with bone cement components and peri-implant histology should be performed after exclusion of frequent complication elicitors (in particular low grade infections). This can show a peri-implant T-lymphocyte dominated inflammation. Additional information on a scientific level is given by the lymphocyte transformation test (LTT) assessing metal sensitivity and by peri-implant molecular cytokine profiling giving the inflammatory pattern.
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