Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).

Pharmacodynamic Models: Overview

Pharmacodynamic Models: Overview

Pharmacodynamic (PD) responses describe the interaction between a drug and its biological target, culminating in a physiological effect. These responses can be classified into different types: continuous variables, such as blood glucose levels; categorical outcomes, like survival rates; and time-to-event metrics, such as disease progression. Understanding and modeling PD responses are critical for optimizing drug efficacy and safety.PD models describe the relationship between drug concentration...

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This relationship...

Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

Pharmacodynamics: Overview and Principles

Pharmacodynamics: Overview and Principles

Pharmacodynamics is a scientific field that delves into drugs' intricate biochemical, cellular, and physiological effects on the human body. The study of pharmacodynamics helps us understand how drugs interact with the body and elicit various responses.
Most drugs' effects result from their interactions with drug receptors or targets within the body. These interactions trigger specific responses at the cellular or systemic level. Drug receptors can be found on the surfaces of cells or within...

Pharmacokinetic Models: Overview

Pharmacokinetic Models: Overview

Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal assumptions,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

WhatsApp group discussion for smoking relapse prevention: a randomised controlled trial (abridged secondary publication).

Hong Kong medical journal = Xianggang yi xue za zhi·2023

Same author

Are we meeting the needs of vulnerable children? Distribution of speech-language pathology services on the Gold Coast, Australia.

Journal of public health (Oxford, England)·2021

Same author

Engineering a bioluminescent bioreporter from an environmentally sourced mercury-resistant Enterobacter cloacae strain for the detection of bioavailable mercury.

Journal of applied microbiology·2019

Same author

Topic: Mesh and Prosthesis.

Hernia : the journal of hernias and abdominal wall surgery·2015

Same author

In-vitro analysis of the dissolution kinetics and systemic availability of plutonium ingested in the form of 'hot' particles from the Semipalatinsk NTS.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2009

Same author

Radioactive prostatic implants: a potential autopsy hazard.

Histopathology·2007

Search research articles

Related Experiment Video

Updated: May 9, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Open access: a new model for publishing in the pharmacological sciences.

¹Shelbyville, Tennessee, USA.

CPT: Pharmacometrics & Systems Pharmacology

|July 10, 2013

Summary

CPT: Pharmacometrics & Systems Pharmacology (CPT:PSP) is a new open-access journal. It allows immediate access to all published articles and permits authors to retain copyright, promoting wider reuse of research.

Area of Science:

Pharmacometrics
Systems Pharmacology

Background:

CPT: Pharmacometrics & Systems Pharmacology (CPT:PSP) is an online-only, open-access journal.
Open access ensures immediate, global accessibility of published research.

Purpose of the Study:

To introduce authors and readers to the publishing approach of the new ASCPT journal, CPT:PSP.
To highlight the benefits of open access and Creative Commons licensing for scholarly publishing.

Main Methods:

Publication on the Nature journal website.
Simultaneous deposit in the PubMed Central repository.
Utilization of a Creative Commons license for authors.

Main Results:

Articles are immediately accessible worldwide upon publication.

More Related Videos

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Related Experiment Videos

Last Updated: May 9, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Authors retain copyright of their work.

Readers can download and reuse published content with attribution.

Conclusions:

The CPT:PSP journal adopts an open-access model to maximize research dissemination.
This model facilitates broader access and reuse of scientific information, benefiting both authors and readers.