Related Experiment Video
Updated: May 9, 2026
12:09
Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
Published on: December 31, 2013
TRPV3: time to decipher a poorly understood family member!
Bernd Nilius1, Tamás Bíró, Grzegorz Owsianik
1Campus Gasthuisberg, Department of Physiology, KU Leuven, Campus Gasthuisberg, Herestraat 49, Leuven B-3000, Belgium. bernd.nilius@med.kuleuven.be.
The Journal of Physiology
|July 10, 2013
Summary
The vanilloid transient receptor potential channel TRPV3 (Transient Receptor Potential Vanilloid 3) is crucial for skin functions like sensation and barrier integrity. Mutations in TRPV3 are linked to rare skin diseases, highlighting its importance.
Area of Science:
- Molecular biology
- Dermatology
- Ion channel research
Background:
- The vanilloid transient receptor potential channel TRPV3 is a unique member of the TRPV subfamily.
- It is regulated by calcium, ATP, and calmodulin.
- TRPV3 is highly expressed in skin keratinocytes.
Purpose of the Study:
- To review the properties and functions of TRPV3 in the skin.
- To discuss the role of TRPV3 in skin diseases.
- To explore TRPV3's function beyond thermosensation.
Main Methods:
- Literature review of TRPV3 properties and functions.
- Analysis of studies on TRPV3 expression patterns.
- Examination of genetic studies linking TRPV3 mutations to skin disorders.
Main Results:
- TRPV3 plays significant roles in skin sensation, hair development, and barrier function.
- Its role as a primary skin thermosensor is debated.
- Mutations in TRPV3 are associated with Olmsted syndrome, a rare genodermatosis.
Conclusions:
- TRPV3 is a key player in various skin functions.
- Understanding TRPV3 is vital for diagnosing and potentially treating related skin diseases.
- Further research is needed to fully elucidate TRPV3's complex roles in the skin.
Related Concept Videos
03:08LTR Retrotransposons
LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
01:43Thermosensation
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
03:18Non-LTR Retrotransposons
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
01:21Repressible Operon: trp Operon
The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...
02:53Conservative Site-specific Recombination and Phase Variation
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
The recognition sites for Cre recombinase called LoxP...
02:13Overview of Transposition and Recombination
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...