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Updated: May 9, 2026
Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
Herpes simplex virus 1 infection on a reconstructive free flap
Simon P Parys1, Thea Leman, Reuven Gurfinkel
1Department of Plastic and Reconstructive Surgery, Sir Charles Gairdner Hospital, Perth, Australia.
Objective:
Herpes simplex virus 1 (HSV1) is a widespread virus that primarily causes orofacial infection.
Methods:
We present a case of HSV1 infection on a free radial forearm flap used to reconstruct a palate defect. Initially, the free flap appeared healthy; however, after 48 hours the free flap appeared in distress, with dark red colour and fast capillary refill. Venous congestion was suspected, and the patient underwent a second operation where no vascular compromise was found. Vesicles were noted on the free flap; swabs revealed HSV1 infection.
Results:
Complete recovery of the free flap was achieved with acyclovir.
Discussion:
To the best of our knowledge, this is the first report of HSV1 infection on a free flap that was found to be responsible for the free flap appearing distressed.
