Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

Clinical Significance of Antibiotic Resistance

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

Special Features of Adaptive Immunity

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Increasing blood pressure predicts levels of circulating neutrophil extracellular traps in untreated hypertensive patients.

Hypertension research : official journal of the Japanese Society of Hypertension·2025

Same author

Soluble triggering receptor expressed on myelocytes-1 compared to procalcitonin in patients with infectious and autoimmune systemic inflammatory response syndrome.

Hippokratia·2016

Same author

PO-53 - Prospective evaluation of risk assessment models and biological markers of hypercoagulability for the identification of high VTE risk patients with lung adenocarcinoma. The ROADMAP study.

Thrombosis research·2016

Same author

Successful response in a case of severe pustular psoriasis after interleukin-1β inhibition.

The British journal of dermatology·2016

Same author

Efficacy and safety of once-weekly glucagon-like peptide 1 receptor agonists for the management of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.

Diabetes, obesity & metabolism·2015

Same author

The influence of therapy on CD4+CD25(high)FOXP3+ regulatory T cells in systemic lupus erythematosus patients: a prospective study.

Scandinavian journal of rheumatology·2014

Search research articles

Related Experiment Video

Updated: May 9, 2026

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Published on: August 5, 2016

Immunity to brucellosis.

P Skendros¹, P Boura

¹First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece. pskendro@med.duth.gr

Revue Scientifique Et Technique (International Office of Epizootics)

|July 11, 2013

Summary

This summary is machine-generated.

Cell-mediated immunity, particularly the T helper type 1 (Th1) response involving interferon-gamma (IFNgamma), is crucial for clearing Brucella infections. However, Brucella employs evasion strategies, complicating immunity and treatment.

More Related Videos

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Published on: May 19, 2023

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

Related Experiment Videos

Last Updated: May 9, 2026

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells

Published on: August 5, 2016

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Determination of Vaccine Immunogenicity Using Bovine Monocyte-Derived Dendritic Cells

Published on: May 19, 2023

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle

Published on: July 11, 2015

Area of Science:

Immunology
Microbiology
Infectious Diseases

Background:

Resistance to Brucella relies on cell-mediated immunity, involving antigen-presenting cells and T-cell expansion.
Brucella antigens stimulate T helper type 1 (Th1) cytokines, with interferon-gamma (IFNgamma) being key for clearance.
Brucella evades host immunity, establishing intracellular niches and causing chronic infections.

Purpose of the Study:

To investigate the role of cell-mediated immunity in Brucella resistance.
To understand Brucella's immune evasion strategies.
To explore challenges in treating chronic brucellosis.

Main Methods:

Analysis of immune responses in experimental and human brucellosis.
Assessment of T helper type 1 (Th1) cytokine production.
Examination of Brucella's impact on host immunity.

Main Results:

An adequate Th1 immune response, driven by IFNgamma, is critical for clearing Brucella.
Brucella utilizes diverse strategies to evade innate and adaptive immunity.
Chronic brucellosis is associated with Th1 response disturbances and anergy, leading to poor outcomes.

Conclusions:

Effective control of Brucella infection hinges on a robust Th1 immune response.
Brucella's immune evasion mechanisms pose significant challenges.
Chronic brucellosis necessitates further research for novel therapeutic and vaccination strategies.