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Related Experiment Videos

Experimental colonic carcinogenesis after gastric surgery.

P W Houghton1, R J Owen, P J Henly

  • 1University Department of Surgery, Bristol Royal Infirmary, UK.

The British Journal of Surgery
|July 1, 1990
PubMed
Summary

Gastric surgery, specifically Pólya partial gastrectomy, does not increase colorectal cancer risk in rats. This procedure may even offer protection by reducing colonic cell proliferation and tumor development.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Surgical Research

Background:

  • Peptic ulcer surgery is suspected to increase colorectal cancer risk.
  • The mechanisms linking gastric operations to colonic carcinogenesis are not fully understood.

Purpose of the Study:

  • To investigate the effects of different gastric operations on colonic cell proliferation, bile acid excretion, and colorectal carcinogenesis in a rat model.
  • To evaluate whether Pólya partial gastrectomy or vagotomy/pyloroplasty influences colorectal tumor development.

Main Methods:

  • 105 male Sprague-Dawley rats underwent sham operation, Pólya partial gastrectomy, or vagotomy and pyloroplasty.
  • Azoxymethane was administered to induce colorectal cancer.
  • Colonic tissues were analyzed for mucosal mass and crypt cell production rate (CCPR).

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  • Fecal samples were assayed for neutral steroids and bile acids.

    • Main Results:

    • Pólya gastrectomy significantly reduced CCPR (42-65%) and the incidence of colorectal tumors (26% vs. 63%).
    • Gastric surgery decreased fecal levels of neutral steroids and bile acids, including hyodeoxycholic acid.
    • Vagotomy and pyloroplasty increased caecal CCPR but did not alter tumor yield or significantly affect fecal steroid levels.

    Conclusions:

    • The study results do not support the hypothesis that gastric surgery predisposes to colonic carcinogenesis.
    • Pólya partial gastrectomy appears to exert a protective effect against colorectal cancer development in rats, likely by inhibiting colonic cell proliferation.