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Related Experiment Video

Updated: May 9, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Published on: June 13, 2022

Further mulinane diterpenoids from Azorella compacta.

Carlos Areche¹, Francisca Rojas-Alvarez, Carolina Campos-Briones

¹Departamento de Química, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile. areche@uchile.cl

The Journal of Pharmacy and Pharmacology

|July 11, 2013

Summary

Azorella compacta yielded new and known diterpenoids with significant gastroprotective activity. Compounds 13β-hydroxyazorellane, azorellanol, and mulin-11,13-dien-18-acetoxy-16,20-dioic acid demonstrated potent ulcer treatment capabilities.

Keywords:

Azorella compacta diterpenoid gastric ulcer llareta mulinane

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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Area of Science:

Natural Product Chemistry
Pharmacology
Medicinal Botany

Background:

Azorella compacta is a plant species known for its traditional medicinal uses.
Diterpenoids, including mulinane and azorellane types, are characteristic secondary metabolites found in Azorella species.

Purpose of the Study:

To isolate and identify characteristic mulinane and azorellane diterpenoids from Azorella compacta.
To evaluate the gastroprotective activity of the isolated compounds using an in vivo model.

Main Methods:

Chemical extraction of Azorella compacta using dichloromethane.
Isolation of compounds via standard chromatographic techniques.
Identification of compounds using spectroscopic methods.
Assessment of gastroprotective activity using the HCl/ethanol-induced gastric lesions model in mice.

Main Results:

Four new diterpenoids (1-3, 12) and eight known diterpenoids (4-9) were isolated, along with two aromatic compounds (10-11).
Compounds 13β-hydroxyazorellane (6), azorellanol (9), and mulin-11,13-dien-18-acetoxy-16,20-dioic acid (12) significantly reduced gastric lesions by 69%, 71%, and 73%, respectively.
The observed gastroprotective effects were comparable to the positive control, lansoprazole.

Conclusions:

The isolated diterpenoids from Azorella compacta exhibit significant gastroprotective activity.
Azorellanol (9) may contribute to the traditional therapeutic uses of Azorella compacta, particularly in ulcer treatment.
The findings support the intraspecific chemical variability in Azorella compacta and highlight the potential of its diterpenoids for pharmaceutical development.