Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fatigue

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...

Fatigue Strength of Concrete

Fatigue Strength of Concrete

Fatigue, in the context of materials science and engineering, refers to the weakening or failure of a material caused by repeatedly applied loads, even if these loads are below the strength limit of the material. Fatigue strength in concrete is a critical property that influences its durability and longevity. Concrete can fail in two ways due to fatigue. Static fatigue or creep rupture occurs under a constant load or one that increases slowly. The other failure mode is due to cyclical or...

Muscle Recovery and Fatigue

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...

Impact Loading

Impact loading occurs when a moving object collides with a stationary structure, such as a rod with a uniform cross-sectional area fixed at one end. Under these conditions, the rod absorbs the kinetic energy from the striking object, leading to deformation and subsequent stress development. As the rod returns to its original position and reaches maximum stress, the absorbed energy, initially manifested as kinetic energy, transforms entirely into strain energy.
In cases of elastic deformation,...

Stress: General Loading Conditions

Stress: General Loading Conditions

To grasp the intricacy of real-world conditions where multiple loads are applied simultaneously to a structure, one might visualize a section passing through a specific point within a body, aligned parallel to the xy plane. This section is subjected to various forces, including original loads, normal forces, and shearing forces.
The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pulsatile low shear stress increases susceptibility to endothelial inflammation via upregulation of IFT and activation of YAP.

APL bioengineering·2025

Same author

Engineering growth factor gradients to drive spatiotemporal tissue patterning in organ-on-a-chip systems.

Journal of tissue engineering·2025

Same author

Production of platelets <i>in vitro</i> in functionalized 3-dimensional scaffolds mimicking the bone marrow niche.

Haematologica·2025

Same author

Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment.

Biomedical materials (Bristol, England)·2023

Same author

Guidelines for ex vivo mechanical testing of tendon.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2023

Same author

The Interfascicular Matrix of Energy Storing Tendons Houses Heterogenous Cell Populations Disproportionately Affected by Aging.

Aging and disease·2023

Search research articles

Related Experiment Video

Updated: May 9, 2026

Ex vivo Mechanical Loading of Tendon

Ex vivo Mechanical Loading of Tendon

Published on: May 28, 2007

Fatigue loading of tendon.

Jennifer H Shepherd¹, Hazel R C Screen

¹Institute of Bioengineering, School of Engineering and Materials Science, Queen Mary, University of London, London E1 4NS, UK. jennifer.shepherd@qmul.ac.uk

International Journal of Experimental Pathology

|July 11, 2013

Summary

This summary is machine-generated.

Tendon overuse causes fatigue damage, leading to microstructural and mechanical changes. This damage correlates with tendinopathy, but cellular responses remain complex.

Keywords:

fatigue mechanics rupture tendinopathy tendon

More Related Videos

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

Published on: March 1, 2024

Related Experiment Videos

Last Updated: May 9, 2026

Ex vivo Mechanical Loading of Tendon

Ex vivo Mechanical Loading of Tendon

Published on: May 28, 2007

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

Published on: March 1, 2024

Area of Science:

Biomedical Engineering
Orthopedics
Sports Medicine

Background:

Tendon injuries (tendinopathies) are common, painful, and often linked to overuse.
The precise causes of tendinopathy initiation and progression are not fully understood.
Current knowledge relies on late-stage disease biopsies, with limited insight into early mechanical and cellular events.

Purpose of the Study:

To review existing models of tendon overuse and fatigue damage.
To synthesize current understanding of how overuse leads to tendinopathy.
To compare findings from various models with clinical tendinopathic tissue data.

Main Methods:

Review of in vitro and in vivo models for studying tendon fatigue.
Analysis of methodologies for characterizing tendon fatigue damage.
Comparison of model-derived data with human tendinopathic tissue biopsies.

Main Results:

Fatigue-induced damage consistently shows similar microstructural, biological, and mechanical changes across different model systems.
These changes observed in models correlate well with findings from tendinopathic biopsy tissues.
Matrix damage is a significant factor in tendinopathy, but cellular responses to fatigue are complex and sometimes contradictory.

Conclusions:

Tendon fatigue damage, characterized by matrix alterations, is a key contributor to tendinopathy.
Existing models provide valuable insights into tendinopathy aetiology.
Further research is needed to clarify the complex cellular responses to tendon fatigue.