Related Experiment Video
Updated: May 9, 2026

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection
Published on: January 31, 2020
[Pre-exposure prophylaxis for HIV transmission? No, unless]
A J P Joan Boeke1, Adrie M Heijnen
1Huisartsenpraktijk Postjesweg, Amsterdam, the Netherlands. ajpboeke@wxs.nl
Abstract:
Pre-exposure prophylaxis (PrEP) with tenofovir/emtricitabine (TDF/FTC) will soon be available in the Netherlands. Moderate evidence concerning practical efficacy, small absolute risk reduction (1-2%) and a high number needed to treat (50-75) are key figures. Prevention of one HIV infection will cost EUR 350,000 to 500,000. No information is available on long-term renal function and antiretroviral resistance. Guidelines are needed before treatment with PrEP is introduced in the Netherlands.
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