Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TRIM47 catalyzes MAVS SUMOylation to safeguard chronic viral infections and tissue inflammation.

Cell communication and signaling : CCS·2026
Same author

Adipocyte OX40L promotes adipose T cell activation and insulin resistance in obesity.

Experimental & molecular medicine·2026
Same author

Genetically modulating the RNA-binding protein Regnase-1 reveals its critical role in regulatory T cell homeostasis and function in vivo.

Cell death & disease·2026
Same author

Cell cycle pathway alterations predict outcomes post-liver transplantation for hepatocellular carcinoma.

Frontiers in transplantation·2026
Same author

Molecular Profiling of Cholangiocarcinoma Predicts Outcomes Post-Liver Transplantation.

JCO precision oncology·2026
Same author

Development and Internal Validation of a Pretransplant Biomarker Panel for Mortality Prediction Following Liver Transplant.

JAMA surgery·2026

Related Experiment Video

Updated: May 9, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Memory T cells in transplantation - progress and challenges.

Xian C Li1, Malgosia Kloc, Rafik M Ghobrial

  • 1Department of Surgery, the Methodist Hospital and Transplant Immunology Program, Methodist Hospital Research Institute, Texas Medical Center, Houston, TX 77030, USA. xcli@tmhs.org

Current Opinion in Organ Transplantation
|July 11, 2013
PubMed
Summary

Memory T cells are crucial for transplant patients, offering protection but also risking transplant rejection. Future tolerance strategies must selectively target harmful alloreactive memory T cells.

More Related Videos

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

Related Experiment Videos

Last Updated: May 9, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Murine Full-thickness Skin Transplantation
07:59

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

Area of Science:

  • Immunology
  • Transplantation Science

Background:

  • Memory T cells are vital for immunity, especially during immunosuppression in transplant patients.
  • However, alloreactive memory T cells pose a significant threat to transplant survival.
  • Balancing their protective and detrimental roles is key for transplant tolerance.

Purpose of the Study:

  • To review the dual role of memory T cells in transplantation.
  • To highlight the challenges and progress in managing memory T cells for transplant tolerance.

Main Methods:

  • Review of recent advancements in understanding memory T cell populations.
  • Analysis of metabolic control and exhaustion pathways in memory T cells.
  • Identification of potential therapeutic targets on memory T cells.

Main Results:

  • Significant progress in characterizing memory T cell diversity and regulation.
  • Identification of key mechanisms and pathways, including cell exhaustion.
  • Multiple therapeutic targets on memory T cells are under investigation in transplant models.

Conclusions:

  • Memory T cells present a 'friend and foe' paradox in transplantation.
  • Effective tolerance strategies require selective targeting of alloreactive memory T cells.
  • Achieving this selective targeting remains a critical clinical challenge.