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Orthotopic Hind Limb Transplantation in the Mouse

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

Tolerance induction: hematopoietic chimerism.

Tatsuo Kawai¹, David H Sachs

¹Transplant Center, Department of Surgery, Massachusetts General Hospital, MA 02114, USA. tkawai@partners.org

Current Opinion in Organ Transplantation

|July 11, 2013

Summary

This summary is machine-generated.

Achieving kidney transplant tolerance is now possible in clinical settings by inducing hematopoietic chimerism. While successful, this method requires further refinement to improve safety and consistency for broader application.

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Area of Science:

Transplantation immunology
Regenerative medicine

Background:

Translating experimental allograft tolerance models to clinical practice remains challenging.
Recent advancements show promise in inducing tolerance for HLA-mismatched kidney transplants.

Purpose of the Study:

To review progress in tolerance induction for preclinical and clinical transplantation.
To summarize recent findings in achieving renal allograft tolerance.

Main Methods:

Review of clinical trials and preclinical models (nonhuman primates).
Focus on induction of mixed or full hematopoietic chimerism.

Main Results:

Successful renal allograft tolerance achieved by combining donor bone marrow with organ transplantation.
Transient or durable mixed chimerism demonstrated in HLA-matched and mismatched recipients.
Full donor chimerism induction reported with intensified conditioning.

Conclusions:

Durable allograft tolerance via hematopoietic chimerism shows excellent long-term outcomes.
Early complications are higher compared to conventional immunosuppression.
Future work focuses on improving safety, consistency, and applicability to other organs.