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Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers

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Published on: August 31, 2021

Influence of nucleus deformability on cell entry into cylindrical structures.

C Giverso¹, A Grillo, L Preziosi

¹Department of Mathematical Sciences, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 , Torino, Italy, chiara.giverso@polito.it.

Biomechanics and Modeling in Mechanobiology

|July 11, 2013

Summary

Cell nucleus mechanics are crucial for cell migration through confined spaces. This study models cell entry into channels, revealing how nuclear deformability and cell adhesion influence movement.

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Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

Biophysical Assays to Probe the Mechanical Properties of the Interphase Cell Nucleus: Substrate Strain Application and Microneedle Manipulation

Published on: September 14, 2011

Area of Science:

Biophysics
Cell Biology
Mechanobiology

Background:

Cellular mechanical properties, particularly of the nucleus, are vital for cell migration.
Understanding cell translocation through confined environments like extracellular matrix channels is key to various biological processes.

Purpose of the Study:

To develop a mathematical model describing cell entry into cylindrical channels.
To derive conditions governing cell translocation through extracellular matrix.

Main Methods:

An energetic approach was employed to model cell entry.
The cell nucleus was modeled as either a liquid droplet with an elastic membrane or as an incompressible Neo-Hookean material.

Main Results:

The study established a necessary condition for cells to enter cylindrical structures.
Results underscore the critical interplay between nuclear mechanical deformability and cell's adhesive and cytoskeletal forces.

Conclusions:

Nuclear mechanical properties significantly impact a cell's ability to navigate confined geometries.
Cellular migration is a complex process influenced by nuclear mechanics, adhesion, and active cytoskeletal forces.