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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: May 9, 2026

Functional Magnetic Resonance Imaging (fMRI) of the Visual Cortex with Wide-View Retinotopic Stimulation
07:11

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Published on: December 8, 2023

Evidence for widespread structural brain changes in glaucoma: a preliminary voxel-based MRI study.

Alice L Williams1, John Lackey, Sheryl S Wizov

  • 1William A. and Anna V. Goldberg Glaucoma Service, Wills Eye Institute, Philadelphia, Pennsylvania, USA.

Investigative Ophthalmology & Visual Science
|July 11, 2013
PubMed
Summary

Glaucoma patients show significant structural brain changes, particularly in occipital and temporal regions. Brain structure alterations correlate with glaucoma severity, indicating widespread cortical involvement.

Keywords:
glaucomastructural MRIvoxel-based morphometry

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In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
12:48

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

Published on: May 11, 2015

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Radiology

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Previous research has primarily focused on ocular changes in glaucoma.
  • Understanding potential central nervous system involvement is crucial.

Purpose of the Study:

  • To investigate structural brain changes in patients with glaucoma.
  • To identify specific brain regions affected by glaucoma.
  • To correlate brain structural changes with glaucoma disease severity.

Main Methods:

  • Acquisition of high-resolution T1-weighted anatomical brain MRI scans.
  • Volumetric analysis of 93 brain structures using an automated technique.
  • Statistical analyses including covariance and multivariate regression.

Main Results:

  • Five brain structures showed significant volume differences between glaucoma patients and controls (P < 0.05).
  • Affected structures included occipital gyri, occipital lobe white matter, and inferior temporal gyrus.
  • Larger volumes were observed in these structures in the glaucoma group compared to controls.
  • A significant correlation was found between decreasing brain structure volume and increased glaucoma severity in 38% of analyzed structures.

Conclusions:

  • Glaucoma is associated with widespread and complex cortical brain structure changes.
  • The extent of these brain structural alterations correlates with the severity of glaucoma.
  • These findings suggest a potential neurodegenerative component extending beyond the optic nerve in glaucoma.