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Related Experiment Video

Updated: May 9, 2026

Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

Published on: September 20, 2024

Changes in ocular monochromatic higher-order aberrations in the aging eye.

Douglas A M Lyall¹, Sathish Srinivasan, Lyle S Gray

¹Department of Ophthalmology, University Hospital Ayr, NHS Ayrshire and Arran, Glasgow, Scotland, United Kingdom.

Optometry and Vision Science : Official Publication of the American Academy of Optometry

|July 11, 2013

Summary

Monochromatic higher-order aberrations (MHOA) in the aging eye show strong inter-eye correlation. Whole eye MHOA increases with age, primarily due to internal ocular changes, not corneal ones.

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Area of Science:

Ophthalmology
Optics
Vision Science

Background:

Aging affects ocular optical quality.
Monochromatic higher-order aberrations (MHOA) contribute to visual degradation.
Understanding age-related MHOA is crucial for ophthalmic interventions.

Purpose of the Study:

To characterize changes in corneal, internal, and total ocular MHOA with age.
To analyze inter-eye correlations of MHOA.
To provide normative data for ophthalmic surgical planning.

Main Methods:

Prospective observational study of 300 eyes from 167 patients (mean age 63.8 years).
Measurement of corneal, internal, and total ocular aberrations over a 6-mm dilated pupil.
Zernike coefficients to the sixth order were analyzed for age-related changes and inter-eye correlations.

Main Results:

Significant inter-eye correlation found for refractive error and MHOA (p < 0.001).
Whole eye MHOA significantly increased with age (p = 0.012), from 0.517 μm to 0.824 μm across decades.
Internal MHOA increased significantly with age (p < 0.025), while corneal MHOA showed no significant age-related changes.

Conclusions:

Strong inter-eye correlation exists for MHOA.
Age-related increases in whole eye MHOA are primarily driven by internal ocular changes.
Normative data on MHOA are valuable for cataract surgeons, particularly when considering aspherical intraocular lenses (IOLs).