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Related Experiment Videos

Patch test sensitivity to the preservative Kathon CG in Spain.

A Hasson1, D Guimaraens, L Condé-Salazar

  • 1Dermatology Department, Ciudad Universitaria, Madrid, Spain.

Contact Dermatitis
|May 1, 1990
PubMed
Summary

Kathon CG, a cosmetic preservative, effectively kills microbes but can cause allergic contact dermatitis. In a study of 626 patients, 3.5% showed positive reactions, primarily women due to cosmetic exposure.

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Area of Science:

  • Dermatology
  • Toxicology
  • Cosmetic Science

Background:

  • Kathon CG is a widely used preservative in cosmetics and toiletries.
  • It demonstrates broad-spectrum antimicrobial efficacy at low concentrations (3-15 ppm).
  • While generally safe at recommended levels, its potential for skin sensitization is recognized.

Purpose of the Study:

  • To evaluate the sensitizing potential of Kathon CG in patients with contact dermatitis.
  • To determine the prevalence and relevance of Kathon CG allergy in a clinical setting.

Main Methods:

  • Patch testing of 626 unselected contact dermatitis patients.
  • Application of Kathon CG solution at 200 ppm active ingredients.
  • Assessment of positive reactions and clinical relevance.

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Main Results:

  • 22 out of 626 patients (3.5%) exhibited positive patch test reactions to Kathon CG.
  • Clinical relevance was established in 7 of these 22 cases.
  • Sensitization predominantly affected women, with cosmetics identified as the primary source.

Conclusions:

  • Kathon CG can cause allergic contact dermatitis, particularly in women.
  • Cosmetics are a significant source of Kathon CG sensitization.
  • Patch testing is crucial for diagnosing Kathon CG allergy in dermatitis patients.