Related Experiment Video
Updated: May 9, 2026

An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
Published on: June 8, 2021
Liver and renal functions following total intravenous anesthesia using midazolam and fentanyl-comparison with
1Department of Anesthesiology, University of Tokyo, Faculty of Medicine, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan.
Abstract:
Thirty patients undergoing lower abdominal surgery were studied to compare liver and renal functions in total intravenous anesthesia (TIVA) using midazolam and fentanyl with those in enflurane-nitrous oxide anesthesia (GOE).Patients were randomly divided into two groups of 15. In the TIVA group, anesthesia was induced with 0.3 mg·kg(-1) midazolam and maintained with 0.68 mg·kg(-1)·h(-1) midazolam for 15 min followed by 0.125 mg·kg(-1)·h(-1) midazolam and fentanyl. In the GOE group, anesthesia was induced with 5 mg·kg(-1) thiamylal and maintained with enflurane-nitrous oxide in oxygen. Plasma levels of aspartate aminotransferase, alanine aminotransferase (ALT), lactate dehydrogenase, total bilirubin, alkaline phosphatase, γ-glutamyl transpeptidase (γ-GTP), blood urea nitrogen (BUN), and creatinine (Cr) were measured before and at 1, 7, and 30 days after surgery. There were transient increases beyond the normal range in ALT and γ-GTP in both groups. BUN and Cr were within the normal range. There were no differences between the two groups regarding these parameters and the numbers with abnormally high levels of each parameter. In conclusion, liver and renal functions following TIVA using midazolam and fentanyl were the same as those following enflurane-nitrous oxide anesthesia.
More Related Videos
08:49Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
09:36Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
Related Concept Videos
Parenteral Anesthetics: Overview
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Inhalational Anesthetics: Overview
Stages of General Anesthesia
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Local Anesthetics: Pharmacokinetics