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Related Concept Videos

Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...
Cytoskeletal Linker Proteins - Plakins01:09

Cytoskeletal Linker Proteins - Plakins

Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
Phosphodiester Linkages01:01

Phosphodiester Linkages

Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.

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Related Experiment Video

Updated: May 9, 2026

Facet-to-facet Linking of Shape-anisotropic Colloidal Cadmium Chalcogenide Nanostructures
09:12

Facet-to-facet Linking of Shape-anisotropic Colloidal Cadmium Chalcogenide Nanostructures

Published on: August 10, 2017

The link in Linking.

Jane C Caldwell1, Pablo A Chiale, Mario D Gonzalez

  • 1Heart Rhythm Service, Queen's University, Kingston, Ontario, Canada.

Indian Pacing and Electrophysiology Journal
|July 11, 2013
PubMed
Summary
This summary is machine-generated.

We describe two cases of atrioventricular nodal reentrant tachycardia (AVNRT) where narrow heartbeats unexpectedly became wide due to aberrant conduction. This aberrancy persisted due to a linking phenomenon involving delayed activation.

Keywords:
Bundle Branch BlockLinking

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Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
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Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

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Facet-to-facet Linking of Shape-anisotropic Colloidal Cadmium Chalcogenide Nanostructures
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Published on: August 10, 2017

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
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Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

Published on: October 15, 2019

Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiac Arrhythmias

Background:

  • Atrioventricular nodal reentrant tachycardia (AVNRT) is a common supraventricular tachycardia.
  • Aberrant intraventricular conduction can complicate the diagnosis and management of cardiac arrhythmias.
  • The slow-fast form of AVNRT typically presents with narrow QRS complexes.

Purpose of the Study:

  • To present two cases of the slow-fast AVNRT form exhibiting an unusual transition from narrow to wide QRS complexes.
  • To elucidate the electrophysiological mechanisms underlying the persistence of aberrant intraventricular conduction during AVNRT.

Main Methods:

  • Case report analysis of two patients with AVNRT.
  • Review of electrocardiographic (ECG) findings, including QRS complex morphology and cycle length variations.
  • Electrophysiological study interpretation to understand conduction patterns.

Main Results:

  • Both cases initially showed narrow QRS complexes characteristic of AVNRT.
  • A transition to wide QRS complexes occurred due to aberrant intraventricular conduction, triggered by specific electrophysiological events (extrastimulus, short-long coupling).
  • The aberrancy pattern persisted due to a
  • linking
  • phenomenon, involving delayed retrograde concealed activation perpetuating bundle branch block.

Conclusions:

  • The slow-fast AVNRT can present with dynamic QRS widening due to aberrant conduction.
  • The "linking" phenomenon, driven by delayed concealed retrograde activation, is crucial in maintaining persistent aberrant conduction after the initial trigger subsides.
  • Understanding these mechanisms is vital for accurate diagnosis and effective management of AVNRT with aberrant conduction.