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Updated: Feb 13, 2026

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
Published on: June 7, 2024
Osteoclasts and CD8 T cells form a negative feedback loop that contributes to homeostasis of both the skeletal and
Zachary S Buchwald1, Rajeev Aurora
1Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 S. Grand Boulevond DRC 605, St. Louis, MO 63104, USA.
Abstract:
There are a number of dynamic regulatory loops that maintain homeostasis of the immune and skeletal systems. In this review, we highlight a number of these regulatory interactions that contribute to maintaining homeostasis. In addition, we review data on a negative regulatory feedback loop between osteoclasts and CD8 T cells that contributes to homeostasis of both the skeletal and immune systems.
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