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Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...

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Related Experiment Video

Updated: May 9, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

Transgelin Up-Regulation in Obstructive Nephropathy.

Fani Karagianni¹, Niki Prakoura, Garyfallia Kaltsa

¹Biomedical Research Foundation of the Academy of Athens, Section of Histology, Center for Basic Research I, Athens, Greece.

|July 11, 2013

Summary

Transgelin, a protein, is elevated in kidney fibrosis following ureteral obstruction. This suggests transgelin may serve as a new biomarker for detecting obstructive nephropathy and renal fibrosis.

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Area of Science:

Nephrology
Molecular Biology
Pathology

Background:

Renal fibrosis is a significant pathological process leading to kidney failure.
Understanding the molecular mechanisms of renal fibrosis is crucial for developing new diagnostic markers.

Purpose of the Study:

To investigate the role of transgelin in the development of renal fibrosis.
To identify potential biomarkers for obstructive nephropathy.

Main Methods:

Proteomic analysis in a rat model of unilateral ureteral obstruction (UUO).
Confirmation of transgelin up-regulation at protein and mRNA levels.
Immunohistochemical analysis to identify cell types expressing transgelin.

Main Results:

Transgelin was found to be up-regulated in renal fibrosis in the UUO model.
Transgelin expression was localized to activated fibroblasts surrounding glomeruli.
Kruppel-like factor 6 was up-regulated in transgelin-positive fibroblasts, suggesting a regulatory role.

Conclusions:

Transgelin is significantly up-regulated in obstructive nephropathy.
Transgelin-expressing activated fibroblasts are key players in renal fibrosis.
Transgelin shows potential as a novel biomarker for renal fibrosis.