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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: May 9, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Published on: February 15, 2022

Lgr4 in ocular development and glaucoma.

Stefan Siwko1, Li Lai, Jinsheng Weng

  • 1Center for Cancer and Stem Cell Biology, Institute for Biosciences and Technology, Texas A & M Health Science Center, Houston, TX 77030, USA.

Journal of Ophthalmology
|July 11, 2013
PubMed
Summary
This summary is machine-generated.

Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) is vital for eye development and preventing glaucoma. Research reviews LGR4

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Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

Area of Science:

  • Ophthalmology
  • Developmental Biology
  • Genetics

Background:

  • Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) is crucial for development.
  • Lgr4 deficiency in mice causes anterior segment dysgenesis and retinal ganglion cell loss.
  • LGR4's role in eye development and glaucoma is an area of active research.

Purpose of the Study:

  • To review LGR4 signaling pathways and their regulation of Pitx2.
  • To explore the connection between LGR4, Norrin, and Wnt signaling in retinal vascularization.
  • To identify research gaps in understanding LGR4's role in glaucoma.

Main Methods:

  • Literature review of LGR4 signaling.
  • Analysis of LGR4's interaction with Pitx2 and Wnt pathway components.
  • Discussion of recent findings on LGR4 as a Norrin receptor.

Main Results:

  • LGR4 regulates the developmental gene Pitx2.
  • LGR4 acts as a receptor for Norrin, potentially influencing retinal vascularization.
  • Lgr4 knockout mice exhibit ocular developmental defects and glaucoma-like phenotypes.

Conclusions:

  • LGR4 is a key player in ocular development and has implications for glaucoma.
  • Understanding LGR4-Norrin-Wnt signaling is critical for retinal vascularization.
  • Further research is needed to fully elucidate LGR4's role in glaucoma pathogenesis.