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Published on: October 10, 2019

Elevated troponin level with negative outcome was found in ischemic stroke

Buse Hasırcı1, Münevver Okay, Dilek Ağırcan

  • 1Department of Neurology, Istanbul Medeniyet University Medical Faculty, 34720 Istanbul, Turkey.

Cardiovascular Psychiatry and Neurology
|July 11, 2013
PubMed

Insights

Elevated cardiac troponin-I (cTnI) levels in acute ischemic stroke patients correlate with more severe neurological deficits and anterior circulation involvement. This finding suggests cTnI may indicate stroke severity.

Area of Science:

  • Neurology
  • Cardiology
  • Biomarkers

Background:

  • Troponin increment is a sensitive marker of myocardial necrosis.
  • The cause of elevated troponin in acute stroke is unclear.
  • Cardiac troponin-I (cTnI) is a specific biomarker for myocardial damage.

Purpose of the Study:

  • To investigate the relationship between cardiac troponin-I (cTnI) levels and acute ischemic stroke.
  • To determine if cTnI elevation is associated with stroke severity or specific stroke characteristics.

Main Methods:

  • Recruited 868 patients with acute ischemic stroke confirmed by diffusion MRI.
  • Excluded patients with other causes of elevated troponin.
  • Included 239 patients, assessing neurological deficits using modified Rankin Scale (mRS) and NIH Stroke Scale (NIHSS).

Main Results:

  • Serum troponin levels were higher in ischemic stroke patients with anterior circulation involvement compared to posterior or hemorrhagic stroke.
  • Higher troponin levels correlated with increased stroke scale scores at discharge in ischemic stroke patients.
  • cTnI levels correlated with stroke scale scores at admission and discharge in posterior stroke patients.

Conclusions:

  • Elevated cTnI is associated with more severe neurological deficits in acute ischemic stroke.
  • cTnI elevation may serve as an indicator of stroke severity and extent.
  • Further research is needed to elucidate the exact mechanisms linking cTnI to stroke outcomes.

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