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Recruiting for epigenetic research: facilitating the informed consent process.

Nancy Jallo1, Debra E Lyon, Patricia Anne Kinser

  • 1School of Nursing, Virginia Commonwealth University, P.O. Box 980567, Richmond, VA 23298, USA.

Nursing Research and Practice
|July 11, 2013
PubMed
Summary
This summary is machine-generated.

Recruiting for epigenetic studies is challenging. Enhanced informed consent using clear explanations and visuals improved understanding and achieved an 89% enrollment success rate in diverse women.

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Area of Science:

  • Biobehavioral science
  • Epigenetics research
  • Genetics and environment

Background:

  • Epigenetic changes link gene-environment interactions to adverse health outcomes.
  • Recruiting participants for genetic and epigenetic studies presents significant challenges.
  • Lack of participant knowledge is a key barrier to recruitment in genetic research.

Purpose of the Study:

  • To share strategies for strengthening the informed consent process in epigenetic research.
  • To provide sample materials designed to improve participant understanding of epigenetics.
  • To report on recruitment success in epigenetic studies involving diverse women.

Main Methods:

  • Developed and implemented enhanced informed consent procedures.
  • Utilized clear recruitment scripts and easy-to-understand illustrations of epigenetic processes.
  • Conducted four epigenetic research studies with diverse women experiencing various health issues.

Main Results:

  • Achieved a combined enrollment success rate of 89% across the four studies.
  • Participants represented a diverse population, indicating broad applicability of the methods.
  • Enhanced recruitment strategies improved participant understanding and engagement.

Conclusions:

  • Strengthened informed consent processes, including clear communication and visual aids, are effective for recruiting participants to epigenetic studies.
  • These strategies can overcome common recruitment barriers, particularly lack of knowledge.
  • The approach facilitated active engagement and encouraged participant questions, leading to high enrollment rates in diverse populations.