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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: May 9, 2026

Orthotopic Mouse Model of Colorectal Cancer
08:43

Orthotopic Mouse Model of Colorectal Cancer

Published on: December 4, 2007

Mouse models for colorectal cancer.

Baktiar O Karim1, David L Huso

  • 1Department of Molecular and Comparative Pathobiology, The Johns Hopkins University Baltimore, MD 21205, USA.

American Journal of Cancer Research
|July 11, 2013
PubMed
Summary

Mouse models are crucial for understanding colorectal cancer (CRC) development and treatment. This review highlights recent advancements in utilizing these models to study CRC biology and inhibition.

Keywords:
ApcColorectal cancerFAPHNPCChumanmouse modelsstem cellstumorigenesis

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Last Updated: May 9, 2026

Orthotopic Mouse Model of Colorectal Cancer
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Area of Science:

  • Oncology
  • Genetics
  • Animal Models

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer death in the US, with increasing incidence.
  • Risk factors include family history, smoking, diet (red meat), obesity, and alcohol.
  • Preventive measures like screening and healthy lifestyle choices reduce CRC risk.

Purpose of the Study:

  • To review advancements in mouse models for studying colorectal cancer (CRC).
  • To emphasize the role of mouse models in understanding CRC pathobiology and therapeutic strategies.

Main Methods:

  • Review of historical and contemporary mouse models used in CRC research.
  • Analysis of how these models contribute to understanding CRC initiation, progression, and inhibition.

Main Results:

  • Mouse models have been instrumental since 1928 in elucidating CRC biology.
  • Recent advancements offer improved fidelity in recapitulating human CRC.
  • These models facilitate the testing of novel therapeutic interventions.

Conclusions:

  • Mouse models are indispensable tools for CRC research.
  • Continued development of sophisticated mouse models will accelerate progress in CRC prevention and treatment.