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Related Experiment Video

Updated: May 9, 2026

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines

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Published on: May 12, 2023

Atomic-scale structures and interactions between the guanine quartet and potassium.

Wei Xu¹, Qinggang Tan, Miao Yu

¹College of Materials Science and Engineering, Key Laboratory for Advanced Civil Engineering Materials (Ministry of Education), Tongji University, Caoan Road 4800, Shanghai 201804, PR China. xuwei@tongji.edu.cn

Chemical Communications (Cambridge, England)

|July 11, 2013

Summary

Atomic-scale identification of the G4K1 motif reveals its high stability. This stability arises from a balance of hydrogen bonding and metal-ligand interactions, crucial for understanding G-quadruplex interactions with cations.

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Last Updated: May 9, 2026

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines

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Published on: May 12, 2023

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Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Published on: September 19, 2017

Area of Science:

Supramolecular Chemistry
Biophysical Chemistry
Materials Science

Background:

G-quadruplex structures are vital nucleic acid motifs with diverse biological roles.
Understanding the stability of specific G-quadruplex motifs is key to their function.
Cation interactions significantly influence G-quadruplex stability and conformation.

Purpose of the Study:

To achieve atomic-scale identification of the G4K1 structural motif.
To elucidate the factors contributing to the high stability of the G4K1 motif.
To provide insights into G-quadruplex interactions with cations in biological systems.

Main Methods:

Scanning Tunneling Microscopy (STM) imaging for atomic-scale visualization.
Density Functional Theory (DFT) calculations for theoretical analysis.
Combined experimental and computational approach.

Main Results:

Successful atomic-scale identification of the G4K1 structural motif.
High stability of the G4K1 motif confirmed.
Stability attributed to a balance between hydrogen bonding and metal-ligand interactions.

Conclusions:

The G4K1 motif possesses significant stability due to synergistic interactions.
This finding is highly relevant for modeling in vivo G-quadruplex-cation interactions.
The study provides a foundation for understanding G-quadruplex recognition and function.