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Degradation of type I and II collagen by human activated C1-s
K Yamaguchi1, H Sakiyama, M Matsumoto
1Division of Physiology and Pathology, National Institute of Radiological Sciences, Chiba, Japan.
FEBS Letters
|July 30, 1990
Abstract:
The activated first component of human complement, C1-s, was shown to cleave type I and II collagen and gelatin. The proteolytic activity was heat labile and was inhibited by a monoclonal antibody (M241) which recognized light chain of active human C1-s or by a serine protease inhibitor, DFP, but not by a chelating agent.