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Updated: May 9, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

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Relationship between placental grade and mean platelet volume.

Ramazan Buyukkaya¹, Ayla Buyukkaya, Muserref Erkan

¹Department of Radiology, School of Medicine, Duzce University , Duzce , Turkey .

|July 12, 2013

Summary

Mean platelet volume, an indicator of platelet function, correlates with placental grade in pregnant women. This finding suggests routine screening of mean platelet volume may help identify placental disorders.

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Area of Science:

Obstetrics and Gynecology
Hematology
Fetal Medicine

Background:

Placental grading using the Grannum scoring system assesses placental maturity.
Mean platelet volume (MPV) serves as an indicator of platelet function and thrombocyte activation.

Purpose of the Study:

To investigate the correlation between mean platelet volume and placental grade (Grannum score).
To determine if mean platelet volume can serve as a marker for functional placental disorders.

Main Methods:

Placental sonographic images were graded using the Grannum scoring system.
Haemogram samples were analyzed for mean platelet volume in pregnant patients during the second and third trimesters.
Linear regression analysis was used to assess the association between Grannum score and mean platelet volume.

Main Results:

A significant, trimester-independent correlation was found between mean platelet volume and placental Grannum score (partial correlation coefficient=0.455; p<0.001).
Placental Grannum score increased significantly with gestational age (p<0.001).
No significant correlation was observed between Grannum score and gravity, parity, or abortion history.

Conclusions:

Mean platelet volume is an independent indicator of placental grade (Grannum score) in the second and third trimesters.
Routine assessment of mean platelet volume may aid in identifying functional placental disorders during pregnancy.