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Related Concept Videos

The Placebo Effect01:54

The Placebo Effect

The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
Blind Procedures02:07

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Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which child was...
Drug Therapy01:28

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Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
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Related Experiment Video

Updated: May 9, 2026

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
08:50

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

Published on: December 14, 2014

The nocebo effect: patient expectations and medication side effects.

Kate Faasse1, Keith J Petrie

  • 1Department of Psychological Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

Postgraduate Medical Journal
|July 12, 2013
PubMed
Summary

Patient expectations significantly influence perceived treatment side effects, often through the nocebo effect. Information provided by healthcare professionals and media can shape these expectations, impacting patient experiences.

Related Experiment Videos

Last Updated: May 9, 2026

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
08:50

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

Published on: December 14, 2014

Area of Science:

  • Psychosomatic Medicine
  • Clinical Pharmacology
  • Health Communication

Background:

  • Patient expectations, influenced by informed consent and external information, play a crucial role in the manifestation of treatment side effects.
  • The nocebo effect, where negative expectations lead to experienced symptoms, is a key mechanism linking expectation to side effects.
  • Misattribution of pre-existing symptoms and healthcare provider beliefs can also contribute to perceived adverse drug events.

Purpose of the Study:

  • To explore the influence of patient expectations on the experience of treatment side effects.
  • To examine the role of the nocebo effect in the realization of anticipated adverse events.
  • To investigate the impact of information sources, including healthcare professionals and media, on patient expectations of side effects.

Main Methods:

  • Literature review and synthesis of existing research on patient expectations and treatment outcomes.
  • Analysis of the psychological mechanisms underlying the nocebo effect.
  • Examination of communication strategies in healthcare and media reporting on medications.

Main Results:

  • A consistent link exists between the expectation of side effects and their actual experience.
  • The nocebo effect is a significant factor in the development of perceived adverse treatment effects.
  • Information provided during informed consent, healthcare provider attitudes, and media coverage can all shape patient expectations.

Conclusions:

  • Patient expectations are a critical determinant of treatment side effect experience, mediated by the nocebo effect.
  • Ethical considerations regarding information disclosure about side effects are paramount for healthcare providers and media.
  • Managing patient expectations is essential for optimizing treatment outcomes and patient well-being.