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Orbital myositis associated with celiac disease
Eren Cerman1, Fehim Esen, Muhsin Eraslan
1Department of Ophthalmology, Marmara University School of Medicine, Istanbul, Turkey, erencerman@yahoo.com.
International Ophthalmology
|July 12, 2013
Summary
This study reports the first case of orbital myositis associated with celiac disease. Prompt diagnosis and treatment with corticosteroids and methotrexate led to symptom relief and disease remission in the patient.
Area of Science:
- Ophthalmology
- Gastroenterology
- Immunology
Background:
- Orbital myositis, an inflammatory condition affecting eye muscles, is often associated with autoimmune disorders.
- Celiac disease is an autoimmune disorder triggered by gluten consumption.
Observation:
- A 26-year-old female presented with right eye redness, eyelid edema, and painful diplopia on left gaze, with limited adduction.
- Orbital MRI confirmed orbital myositis.
- Serological tests revealed positive antibodies for celiac disease (anti-endomysial IgA/IgG, anti-gliadin IgA, anti-tissue transglutaminase IgG).
Findings:
- The patient's symptoms resolved with methylprednisolone therapy.
- Due to steroid dependence, methotrexate was initiated, leading to sustained remission.
- This case establishes a novel association between orbital myositis and celiac disease.
Implications:
- Highlights the importance of considering celiac disease in patients with orbital myositis, especially with gastrointestinal symptoms.
- Suggests a potential autoimmune link between these two conditions.
- Emphasizes the efficacy of immunosuppressive therapy in managing associated orbital myositis.
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