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Updated: May 9, 2026

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions
Published on: March 22, 2018
Inducing chaos in a gene regulatory network by coupling an oscillating dynamics with a hysteresis-type one
1Mathematics Laboratory J.A Dieudonné, University of Nice Sophia Antipolis, UMR CNRS 7351, 06108 , Nice Cedex 02, France, Camille.POIGNARD@unice.fr.
Abstract:
In this paper, we investigate the chaotic behavior of a gene regulatory network modeled by four differential equations and seventeen parameters. This network, called [Formula: see text]-system, has been designed to couple in a simple way an oscillating system with one having a bistable switch. After having studied it analytically, we exhibit (by a constructive proof) the mechanism responsible of chaos for a general differential system presenting such a coupling. Namely, given a generic one-parameter family of smooth vector fields on [Formula: see text] presenting a Hopf bifurcation, we prove that under an assumption on the Jacobian at the bifurcation point, we can create such a chaotic system by perturbing the parameter thanks to a hysteresis-type dynamics. Finally, we numerically show that the mechanism highlighted previously takes place in the [Formula: see text]-system, for a particular set of values of its parameters.
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