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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

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Related Experiment Video

Updated: May 9, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Deconstructing vitamin D deficiency.

Lorenz C Hofbauer1, Christine Hamann

  • 1Division of Endocrinology, Diabetes and Bone Diseases, Dresden Technical University Medical Center, D-01307 Dresden, Germany. lorenz.hofbauer@uniklinikum-dresden.de

Science Translational Medicine
|July 12, 2013
PubMed
Summary
This summary is machine-generated.

Vitamin D deficiency accelerates bone aging, leading to increased microcracks in bone tissue. This highlights the critical role of vitamin D in maintaining bone integrity and preventing age-related bone damage.

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Last Updated: May 9, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Area of Science:

  • Bone Biology
  • Mineral Metabolism
  • Aging Research

Background:

  • Vitamin D is essential for calcium absorption and bone health.
  • Deficiency is linked to various bone pathologies.
  • Bone aging involves structural degradation and reduced mechanical properties.

Purpose of the Study:

  • To investigate the impact of vitamin D deficiency on bone aging.
  • To examine the accumulation of microcracks in bone tissue due to vitamin D deficiency.

Main Methods:

  • Histological analysis of bone tissue.
  • Micro-computed tomography (micro-CT) for structural assessment.
  • Evaluation of microcrack density and distribution.

Main Results:

  • Vitamin D deficiency resulted in significantly advanced aging of bone tissue.
  • A notable accumulation of microcracks was observed in the bone tissue of deficient subjects.
  • Bone structural integrity was compromised, correlating with increased microcrack formation.

Conclusions:

  • Vitamin D deficiency is a key factor in accelerating bone aging.
  • Microcrack accumulation is a significant consequence of vitamin D deficiency, impairing bone quality.
  • Maintaining adequate vitamin D levels is crucial for preserving bone health and preventing age-related bone deterioration.