CFS in Children and Adolescent: Ten Years of Retrospective Clinical Evaluation

Irene Elgen1, Omar Hikmat, Tora N Aspevik

  • 1Department of Child and Adolescent Psychiatry, Haukeland University Hospital, 5021 Bergen, Norway ; Department of Clinical Medicine, University of Bergen, P.O Box 7804, 5020 Bergen, Norway.

Insights

An increasing number of children are evaluated for chronic fatigue syndrome (CFS). A systematic, multidisciplinary approach is essential for accurate diagnosis and care.

Area of Science:

  • Pediatrics
  • Neurology
  • Infectious Diseases

Background:

  • Chronic Fatigue Syndrome (CFS) diagnosis in pediatric populations presents unique challenges.
  • Understanding the epidemiology and clinical characteristics of pediatric CFS is crucial for effective management.

Purpose of the Study:

  • To estimate the number of children diagnosed with chronic fatigue syndrome (CFS).
  • To analyze the clinical presentation and outcomes of pediatric CFS cases.

Main Methods:

  • Retrospective data collection over 10 years (2002-2011) from children referred for fatigue symptoms.
  • Analysis of diagnostic codes, patient history, infection markers, and anthropometric data.

Main Results:

  • 27 children received a CFS diagnosis (G93.3) after exclusions.
  • Most cases reported fatigue onset post-infection (Epstein-Barr virus, cytomegalovirus, or borrelia).
  • Underweight (BMI < 17.5) was noted in 44% of patients; 59% were boys.

Conclusions:

  • There is an observed increase in pediatric CFS evaluations.
  • Systematic clinical assessment, including nutritional, eating disorder, and psychosocial factors, is vital.
  • A multidisciplinary approach and European guidelines are needed for pediatric CFS assessment.

Related Concept Videos

Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic sinusitis...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...