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Related Concept Videos

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Related Experiment Video

Updated: May 9, 2026

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
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Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Published on: February 28, 2025

Predicting and analyzing interactions between Mycobacterium tuberculosis and its human host.

Holifidy A Rapanoel1, Gaston K Mazandu, Nicola J Mulder

  • 1Computational Biology Group, Department of Clinical Laboratory Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

Plos One
|July 12, 2013
PubMed
Summary

Understanding Mycobacterium tuberculosis (Mtb) infection requires mapping host-pathogen protein interactions. This study predicts 190 human-Mtb interactions, revealing Mtb

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Last Updated: May 9, 2026

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Preparation of Mycobacterium tuberculosis Culture Filtrate to Understand TB Pathogenesis
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Area of Science:

  • Microbiology
  • Immunology
  • Bioinformatics

Background:

  • Mycobacterium tuberculosis (Mtb) infection outcome hinges on host response and bacterial manipulation via protein-protein interactions.
  • Elucidating human-Mtb interactions is crucial for understanding bacterial persistence and survival mechanisms.

Purpose of the Study:

  • To predict and analyze functional protein-protein interactions between humans and Mtb.
  • To identify molecular mechanisms underlying Mtb persistence and potential drug targets.

Main Methods:

  • Utilized the interologs method, integrating intra- and inter-species interactions.
  • Filtered predicted interactions using known human-Mtb data and differentially expressed genes.
  • Performed subcellular localization and functional enrichment analysis of interacting proteins.

Main Results:

  • Identified 190 high-confidence human-Mtb interactions.
  • Human proteins implicated in apoptosis and nitric oxide production; Mtb proteins relevant to intracellular survival.
  • Pathway analysis revealed involvement in the tuberculosis pathway and potential nutrient acquisition by Mtb.

Conclusions:

  • Predicted interactions offer insights into the human-Mtb interplay.
  • Findings contribute to understanding Mtb pathogenesis and designing novel anti-tuberculosis drugs.