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MicroRNA analysis in placentas from patients with preeclampsia: comparison of new and published results
James S Betoni1, Kimberly Derr, Matthew C Pahl
1Department of Maternal Fetal Medicine, Geisinger Clinic , Danville, PA , USA .
Objective:
The aim was to identify differences in microRNA expression between patients with and without preeclampsia.
Methods:
Microarray-based study was carried out with placental samples.
Results:
Comparison of eight previous studies with the current study revealed a total of 138 microRNAs; only 20/138 (14%), however, were seen in more than one study and the results agreed in the direction of change. Bioinformatic analysis of these 20 microRNAs identified a wide range of biological functions including apoptosis and cell movement for their mRNA targets.
Conclusion:
The associations between miRNA expression and preeclampsia suggest a potential role for microRNAs in preeclampsia pathobiology.
