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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

Updated: May 9, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Progress in understanding the association between high myopia and primary open-angle glaucoma.

Fei Ma1, Jinhui Dai, Xinghuai Sun

  • 1Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China; Key Laboratory of Myopia, Ministry of Health PR China, Shanghai, China.

Clinical & Experimental Ophthalmology
|July 13, 2013
PubMed
Summary

High myopia and primary open-angle glaucoma share common features and interact. Research explores their molecular links, focusing on genetics and collagen changes to understand this association.

Keywords:
TIGR geneglaucomaglucocorticoidhigh myopia

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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Published on: May 25, 2020

Related Experiment Videos

Last Updated: May 9, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Area of Science:

  • Ophthalmology
  • Genetics
  • Molecular Biology

Background:

  • High myopia (HM) and primary open-angle glaucoma (POAG) exhibit a significant clinical association.
  • The progression of HM appears to influence the occurrence and advancement of POAG.
  • Existing theories suggest shared genetic factors, including hypertension and collagen-related genes, may underlie this link.

Purpose of the Study:

  • To review current research on the association between high myopia and primary open-angle glaucoma.
  • To explore epidemiological, clinical, and pathogenic aspects of this comorbidity.
  • To highlight molecular genetics as a tool for elucidating shared mechanisms.

Main Methods:

  • Literature review of clinical and fundamental studies.
  • Analysis of research from epidemiological, clinical, and molecular perspectives.
  • Examination of proposed pathogenic mechanisms, including genetic and collagen-related theories.

Main Results:

  • High myopia and POAG patients demonstrate similar collagen alterations.
  • Both conditions show hypersensitive responses to glucocorticoids.
  • Molecular genetics offers potential insights into the shared underlying mechanisms.

Conclusions:

  • The association between high myopia and primary open-angle glaucoma is supported by clinical and molecular evidence.
  • Shared collagen changes and glucocorticoid sensitivity point to common pathogenic pathways.
  • Further molecular genetic research is crucial for a comprehensive understanding of this relationship.