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Related Experiment Video

Updated: May 9, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Obesity, diabetes and periodontitis--a triangular relationship?

¹Department of Oral Surgery, Leeds Dental Institute and Academic Unit of Obstetrics, Gynaecology and Paediatrics, University of Leeds, UK. r.s.levine@leeds.ac.uk

British Dental Journal

|July 13, 2013

Summary

Obesity and type 2 diabetes are rising globally, increasing the risk of periodontal disease. Treating gum disease may improve glycaemic control, highlighting a link between oral health and systemic conditions.

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Last Updated: May 9, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Area of Science:

Oral Health and Systemic Disease
Metabolic Syndrome Research
Inflammatory Disease Mechanisms

Background:

Global obesity and type 2 diabetes rates are increasing, posing significant health and economic challenges.
Both diabetes types are established risk factors for periodontal disease.
Emerging evidence suggests obesity directly and indirectly impacts periodontal health via inflammation and glycaemic control.

Purpose of the Study:

To explore the intricate relationship between obesity, type 2 diabetes, and periodontal disease.
To investigate the potential for periodontitis to exacerbate glycaemic control.
To propose a triangular model of interconnected morbidity.

Main Methods:

Review of current scientific literature on obesity, diabetes, and periodontal disease.
Analysis of the role of adipose tissue-derived inflammatory agents.
Examination of glycaemic control changes following periodontal treatment.

Main Results:

Obesity acts as both an indirect risk factor (affecting glycaemic control) and a direct risk factor (via adipose tissue inflammation) for periodontal disease.
Periodontitis may negatively impact glycaemic control, suggesting a bidirectional relationship.
A potential self-perpetuating cycle exists linking obesity, type 2 diabetes, and periodontal disease through inflammation.

Conclusions:

Dentists should assess glycaemic control and adiposity in periodontitis patients.
Collaboration between dental and medical practitioners is crucial for managing these interconnected conditions.
Periodontal treatment may reduce the risk of diabetic co-morbidities and systemic disease development.