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Detection of Enterohemorrhagic Escherichia Coli Colonization in Murine Host by Non-invasive In Vivo Bioluminescence System
Published on: April 9, 2018
Risk factors for developing ESBL E. coli: can clinicians predict infection in patients with prior colonization?
T Goulenok1, A Ferroni, E Bille
1Assistance Publique-Hôpitaux de Paris, Laboratoire de Microbiologie, Hôpital Necker-Enfants Malades, Paris, France.
The Journal of Hospital Infection
|July 13, 2013
Summary
Patients previously colonized with extended-spectrum β-lactamase-producing Escherichia coli (ESBLEC) face increased infection risk. Urinary catheterization and prior β-lactam/β-lactamase inhibitor use are key risk factors for developing ESBLEC infection.
Area of Science:
- Infectious Diseases
- Microbiology
- Hospital Epidemiology
Background:
- Extended-spectrum β-lactamase-producing Escherichia coli (ESBLEC) is a growing concern in hospital-acquired infections.
- While risk factors for ESBLEC colonization and infection are known, those for infection development in previously colonized patients are less understood.
Purpose of the Study:
- To identify specific risk factors associated with the development of ESBLEC infection in patients already colonized with ESBLEC.
Main Methods:
- A retrospective case-control study was conducted at Hôpital Necker-Enfants Malades between 2007 and 2010.
- A multivariable model analyzed data from 118 patients, comparing those with nosocomial ESBLEC infection post-colonization to a control group with colonization alone.
Main Results:
- Urinary catheterization (OR 5.2) and prior use of β-lactam/β-lactamase inhibitors (OR 3.2) were identified as significant risk factors for ESBLEC infection in colonized patients.
- The median time from colonization to infection was 12.5 days.
- Urinary tract infections constituted the majority (85%) of ESBLEC infections.
Conclusions:
- Identifying these risk factors aids in pinpointing colonized patients who may require antibiotic treatment for nosocomial ESBLEC infections.
- Preventative strategies should focus on judicious use of specific antibiotics and controlled duration of urinary catheterization to mitigate infection risk.
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