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Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.

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Related Experiment Video

Updated: May 9, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Trametinib: first global approval.

Cameron J M Wright1, Paul L McCormack

  • 1Adis R & D Insight, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore, 0754, Auckland, New Zealand. dru@adis.com

Drugs
|July 13, 2013
PubMed
Summary
This summary is machine-generated.

Trametinib, a MEK inhibitor, targets BRAF-mutated cancers by blocking cell signaling. It has gained approval for melanoma and is under investigation for other cancers, alone and in combination therapies.

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Published on: October 27, 2014

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Trametinib is an orally bioavailable inhibitor of mitogen-activated protein kinase (MAPK) kinase (MEK) 1 and 2.
  • It targets growth factor-mediated cell signaling and proliferation in various cancers.

Purpose of the Study:

  • To summarize the development milestones of trametinib.
  • To highlight its first approval for unresectable or metastatic BRAF mutation-positive malignant melanoma.

Main Methods:

  • Review of clinical development data for trametinib.
  • Analysis of regulatory submissions and clinical trial outcomes.

Main Results:

  • Trametinib approved in the US as monotherapy for BRAF V600E/K-mutated melanoma.
  • Ongoing Phase II/III trials for pancreatic cancer, non-small cell lung cancer, leukaemias, and melanoma in combination with dabrafenib.
  • Combination therapy with dabrafenib shows promise in colorectal cancer and other solid tumors.

Conclusions:

  • Trametinib represents a significant advancement in targeted cancer therapy.
  • Its efficacy in BRAF-mutated melanoma and potential in other malignancies underscore its therapeutic value.