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Updated: May 9, 2026
12:04
Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
Published on: August 14, 2012
Neuroendocrine tumors: treatment updates
Simon Khagi1, Muhammad Wasif Saif
1Tufts Medical Center, Tufts University School of Medicine. Boston, MA 02111, USA. skhagi@tuftsmedicalcenter.org
JOP : Journal of the Pancreas
|July 13, 2013
Summary
Advanced gastroenteropancreatic neuroendocrine tumors are challenging to treat. Novel targeted therapies are emerging, showing promise for improved treatment options for neuroendocrine malignancies.
Area of Science:
- Oncology
- Gastroenterology
- Medical Oncology
Background:
- Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) represent a challenging group of neoplasms with limited systemic treatment options for advanced and metastatic disease.
- The landscape of GEP-NET treatment has seen advancements, with the 2011 approval of targeted therapies everolimus and sunitinib for pancreatic neuroendocrine tumors.
- This progress has spurred increased interest in novel therapeutic agents for these malignancies.
Purpose of the Study:
- To highlight new therapeutic options for neuroendocrine tumors presented at the 2013 American Society of Clinical Oncology (ASCO) conference.
- To underscore the growing focus on neuroendocrine tumors within the oncology community, as evidenced by dedicated sessions at ASCO.
- To provide insight into novel agents targeting unique pathways in neuroendocrine malignancies.
Main Methods:
- Review of abstracts presented at the 2013 ASCO conference, specifically those under the new 'neuroendocrine tumor' title.
- Focus on abstracts #4030, #4031, #4032, and #4136, which address new therapeutic strategies.
- Analysis of emerging treatments for advanced and metastatic gastroenteropancreatic neuroendocrine tumors.
Main Results:
- The 2013 ASCO conference featured four abstracts dedicated to neuroendocrine tumors, indicating heightened research interest.
- These abstracts presented novel therapeutic options targeting specific pathways in neuroendocrine malignancies.
- The findings suggest a shift towards more targeted and potentially effective treatments for GEP-NETs.
Conclusions:
- The development and approval of targeted therapies like everolimus and sunitinib have accelerated research into novel agents for GEP-NETs.
- The dedicated neuroendocrine tumor session at ASCO 2013 signifies a growing recognition of the need for specialized treatment strategies.
- Emerging therapeutic options presented at ASCO 2013 offer new hope for patients with advanced and metastatic gastroenteropancreatic neuroendocrine tumors.
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