A new diamond biosensor with integrated graphitic microchannels for detecting quantal exocytic events from chromaffin
Federico Picollo1, Sara Gosso, Ettore Vittone
1Department of Physics, NIS Centre of Excellence, CNISM Research Unit - University of Torino, INFN Sez. Torino, via P. Giuria 1, Torino, 10125, Italy. picollo@to.infn.it.
Advanced Materials (Deerfield Beach, Fla.)
|July 13, 2013
Abstract:
An MeV ion-microbeam lithographic technique can be successfully employed for the fabrication of an all-carbon miniaturized cellular biosensor based on graphitic microchannels embedded in a single-crystal diamond matrix. The device is functionally characterized for the in vitro recording of quantal exocytic events from single chromaffin cells, with high sensitivity and signal-to-noise ratio, opening promising perspectives for the realization of monolithic all-carbon cellular biosensors.
