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Related Concept Videos

The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Microbial Mats01:25

Microbial Mats

Microbial communities forming biofilms and mats represent complex, spatially structured ecosystems where metabolic processes are stratified according to light, oxygen, and nutrient gradients. Biofilms are initial colonization stages, only a few millimeters thick, while mature microbial mats can reach centimeter-scale thickness and display intricate vertical organization. Their structural and functional heterogeneity allows microorganisms to occupy distinct ecological niches within a few...

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Related Experiment Video

Updated: May 9, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
14:55

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

Multilevel hierarchically ordered artificial biomineral.

Xiaoguo Liu1, Kaili Lin, Chengtie Wu

  • 1University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200050, PR China; State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China, Fax: (+)86-21-52413903.

Small (Weinheim an Der Bergstrasse, Germany)
|July 13, 2013
PubMed
Summary
This summary is machine-generated.

Scientists created a biomimetic material, a hydroxyapatite and gelatine composite, that mimics bone

Keywords:
biomimeticsbiomineralshard templateshierarchical structureshydroxyapatite

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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Published on: February 23, 2017

Related Experiment Videos

Last Updated: May 9, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
14:55

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications
05:41

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Published on: February 23, 2017

Area of Science:

  • Biomaterials Science
  • Materials Engineering
  • Biomineralization

Background:

  • Living organisms produce complex organic-inorganic hybrid materials (e.g., bone, teeth) with superior properties.
  • Mimicking these natural structures has been challenging, with limited practical success.
  • Hierarchical structures in biological materials contribute to their enhanced functions.

Purpose of the Study:

  • To develop a multilevel hierarchically ordered artificial biomineral.
  • To create a hydroxyapatite/gelatine composite with biomimetic nanomechanical properties.
  • To explore a novel approach for hard tissue engineering applications.

Main Methods:

  • Fabrication of a hydroxyapatite (HAp)/gelatine hybrid material.
  • Utilized a hard template approach for bottom-up crystal construction (nano- to macroscale).
  • Achieved phase transformation from dicalcium phosphate (DCP) to HAp.

Main Results:

  • The artificial biomineral exhibited favorable nanomechanical properties.
  • Optimized HAp/gelatine material showed a modulus of 25.91 GPa and hardness of 0.90 GPa.
  • These properties closely match those of human cortical bone (modulus 24.3 GPa, hardness 0.69 GPa).

Conclusions:

  • A novel biomimetic material with hierarchical structure and bone-like mechanical properties was successfully synthesized.
  • The bottom-up crystal construction method provides a new strategy for mimicking sclerous tissues.
  • This material holds significant potential for hard tissue engineering applications.