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Azathioprine and allopurinol: a potentially dangerous combination
G Venkat Raman1, V L Sharman, H A Lee
1Department of Renal Medicine, University of Southampton, St Mary's Hospital, Portsmouth, UK.
Journal of Internal Medicine
|July 1, 1990
Abstract:
We report the association of leucopenia and anaemia in five patients given a combination of azathioprine and allopurinol. Three subjects were renal transplant recipients with mild to moderate impairment of graft function. The complication appeared between 4 and 6 weeks following initiation of the combination therapy. Discontinuation of one of the two drugs resulted in full recovery within 4-8 weeks.