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Related Experiment Video

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High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

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The Integrated Web Portal for Escalation with Overdose Control (EWOC).

Haibin Wang¹, Mourad Tighiouart, Shao-Chi Huang

¹Biostatistics & Bioinformatics Research Center, Cedars-Sinai Medical Center, 116 N. Robertson Blvd, Los Angeles, CA 90048, USA.

The Open Medical Informatics Journal

|July 13, 2013

Summary

This study introduces a new web portal for designing cancer Phase I clinical trials using the Escalation with Overdose Control (EWOC) method. The portal offers a user-friendly dose-finding calculator and downloadable software to aid researchers.

Keywords:

Bayesian method EWOC cancer phase I clinical trial maximum tolerated dose open source.

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Area of Science:

Oncology
Biostatistics
Clinical Trial Design

Background:

Cancer Phase I clinical trials are crucial for determining safe and effective drug dosages.
The Escalation with Overdose Control (EWOC) is a statistical method for designing these trials.
Existing tools for EWOC implementation may lack accessibility or user-friendliness.

Purpose of the Study:

To design and implement a novel, accessible web portal for the EWOC method in cancer Phase I clinical trials.
To provide both a web-based dose-finding calculator and downloadable software for EWOC implementation.
To facilitate the design and execution of dose-finding studies using EWOC methodology.

Main Methods:

Development of a database-driven, distributed computing platform for dose-finding calculations.
Implementation using open-source technologies including PHP, JQuery, R, and OpenBUGS.
Creation of a web-based calculator accessible via standard browsers and a standalone Windows application.

Main Results:

A functional web portal integrating a dose-finding calculator and downloadable software for EWOC.
The portal supports standard web browsers and offers a downloadable Windows application.
The platform is built on industry standards and open-source software for broad accessibility.

Conclusions:

The developed web portal provides a valuable, accessible resource for researchers designing cancer Phase I clinical trials.
The EWOC methodology is effectively implemented through this integrated web-based and standalone software solution.
This tool aims to streamline the process of dose-finding in early-phase cancer drug development.