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Related Experiment Video

Updated: May 9, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Versatile optical coherence tomography for imaging the human eye.

Aizhu Tao¹, Yilei Shao, Jianguang Zhong

¹Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136, USA ; School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang 325027, China.

Biomedical Optics Express

|July 13, 2013

Summary

This summary is machine-generated.

A novel CMOS-based spectral domain OCT (SD-OCT) system enables versatile in vivo ophthalmic imaging. This adaptable system provides high-resolution visualization of the entire eye, from the cornea to the retina.

Keywords:

(170.3880) Medical and biological imaging (170.4500) Optical coherence tomography (170.4580) Optical diagnostics for medicine (330.4460) Ophthalmic optics and devices

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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

Area of Science:

Ophthalmic imaging
Biomedical optics
Medical instrumentation

Background:

Spectral domain optical coherence tomography (SD-OCT) is a crucial non-invasive imaging modality in ophthalmology.
Existing SD-OCT systems can be limited in their versatility for imaging diverse ocular structures.
A need exists for a simplified, adaptable SD-OCT system capable of comprehensive eye imaging.

Purpose of the Study:

To demonstrate the feasibility of a versatile, CMOS-based SD-OCT system for in vivo ophthalmic imaging.
To showcase the system's capability for imaging various ocular structures, including the anterior segment, crystalline lens, and retina.
To validate the system's performance in terms of resolution, scan depth, and speed.

Main Methods:

Development of a CMOS-based SD-OCT system utilizing a single spectrometer and an alternating reference arm with four mirrors.
Implementation of a galvanometer scanner to switch the reference beam for different imaging applications.
Achieved axial resolution of 7.7 μm, scan depth up to 37.7 mm, and scan speed of 70,000 A-lines/second.

Main Results:

High-resolution imaging of the corneal epithelium, limbus, ocular surface, contact lens, and tear meniscus was achieved.
The system successfully imaged the entire anterior segment by registering images with alternating zero delay lines.
Retinal imaging, including the macula and optic nerve head, was performed by incorporating a 60 D lens.

Conclusions:

The developed CMOS-based SD-OCT system offers remarkable versatility and simplicity for multi-purpose ophthalmic applications.
This adaptable system can image the full eye in vivo, from superficial ocular structures to the posterior pole.
The findings support the potential of this SD-OCT technology for broad clinical and research use in ophthalmology.