Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human decidual gamma/delta T cells possess unique effector and TCR repertoire profiles during pregnancy.

Cellular immunology·2022
Same author

Some comments on Bitcoin market (in)efficiency.

PloS one·2019
Same author

Doppler-guided transanal hemorrhoidal dearterilization versus conventional hemorrhoidectomy for treatment of hemorrhoids - early and long-term postoperative results.

BMC surgery·2019
Same author

Mother-to-newborn transmission of mycobacterial L-forms and Vδ2 T-cell response in placentobiome of BCG-vaccinated pregnant women.

Scientific reports·2017
Same author

[ANTITHROMBOTIC MEDICATION IN PREGNANT WOMEN WITH PREVIOUS INTRAUTERINE GROWTH RESTRICTION].

Akusherstvo i ginekologiia·2016
Same author

TRENDS AND ALTERNATIVES IN TREATMENT OF MALIGNANT TUMORS OF EXTRAHEPATIC BILE DUCTS.

Khirurgiia·2016

Related Experiment Video

Updated: May 9, 2026

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

Gastrointestinal stromal tumors.

I Taneva1, V Dimitrova

  • 1Clinic of General and Hepato-Pancreatic Surgery, University Hospital "Alexandrovska", Medical University, Sofia.

Khirurgiia
|July 16, 2013
PubMed
Summary

Gastrointestinal stromal tumors (GISTs) are rare and difficult to diagnose due to non-specific signs. Surgical resection is primary, with Imatinib therapy for unresectable cases.

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Medical Oncology

Background:

  • Gastrointestinal stromal tumors (GISTs) are rare neoplasms.
  • Diagnosis of GISTs presents challenges due to a lack of specific clinical, laboratory, and imaging findings.

Purpose of the Study:

  • To summarize the diagnostic and therapeutic challenges of GISTs.
  • To highlight the importance of surgical and medical management.

Main Methods:

  • Review of diagnostic criteria for GISTs.
  • Analysis of treatment modalities for resectable and non-resectable GISTs.

Main Results:

  • GIST diagnosis is often delayed due to non-specific presentation.
  • Surgery is the primary treatment for resectable GISTs.

More Related Videos

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
06:43

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib

Published on: April 3, 2026

Related Experiment Videos

Last Updated: May 9, 2026

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
06:43

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib

Published on: April 3, 2026

  • Imatinib is the standard therapy for non-resectable GISTs.

    • Conclusions:

    • Accurate diagnosis of GISTs requires a high index of suspicion.
    • Multidisciplinary approach is crucial for optimal GIST management.
    • Targeted therapy with Imatinib has significantly improved outcomes for advanced GISTs.