[Oxidative stress; a comparative study between normal and morbid obesity group population]

Area of Science:

• Biochemistry
• Clinical Medicine
• Obesity Research

Background:

• Obesity is a complex condition associated with numerous health risks.
• Oxidative stress (OS) plays a role in the pathophysiology of various diseases.
• Understanding OS levels in morbid obesity is crucial for clinical management.

Purpose of the Study:

• To quantify oxidative stress markers in morbidly obese patients.
• To compare OS levels between morbidly obese individuals and a healthy control group.
• To investigate the status of antioxidant systems in morbid obesity.

Main Methods:

• Blood and urine samples were analyzed for key OS metabolites (MDA, 8-oxo-dG, GSSG/GSH ratio) and glutathione (GSH).
• Statistical analyses included descriptive statistics, Kolmogorv-Smirnov test, Student's t test, and Mann-Whitney U test.
• A significance level of p < 0.05 was used for hypothesis testing.

Main Results:

• The morbidly obese group (n=28, BMI 50.1±4) showed significantly higher OS metabolite levels than the normal-weight group (n=28, BMI 23.9±6).
• Antioxidant system activity (GSH) was reduced in morbidly obese patients.
• Comorbidities were prevalent in the obese group (67.8%), while absent in the control group.

Conclusions:

• Elevated OS metabolite levels in morbidly obese patients confirm OS at a pathological level.
• The findings highlight a significant imbalance in redox status in morbid obesity.
• These results underscore the systemic impact of obesity on oxidative stress pathways.