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Published on: March 14, 2017
[Anemia and iron deficiency in children with chronic respiratory diseases]
Salesa Barja1, Eduardo Capo, Lilian Briceño
1Departamento de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile. sbarja@puc.cl
Insights
Iron deficiency and anemia are common in children with chronic respiratory disease (CRD). Prophylactic iron supplementation can prevent the depletion of iron reserves in these vulnerable children.
Area of Science:
- Pediatric Pulmonology
- Hematology
- Nutritional Science
Background:
- Children with chronic respiratory disease (CRD) face a higher risk of iron deficiency and anemia.
- This condition is frequently under-diagnosed in this population.
Purpose of the Study:
- To assess the iron status in pediatric patients diagnosed with CRD.
- To evaluate the impact of prophylactic iron supplementation on iron status and related biomarkers.
Main Methods:
- A prospective study involving children with CRD and adequate dietary iron intake.
- Baseline measurements included hemogram, C-reactive protein, and iron profile.
- Children were divided into two groups: one without iron supplementation and another receiving supplementation for iron deficiency anemia or at risk.
Main Results:
- At baseline, 20% of children were anemic and 12.5% had abnormal iron profiles.
- In the non-supplemented group, serum ferritin decreased over 3 months but recovered by 4 months.
- The supplemented group showed a significant increase in hemoglobin levels.
Conclusions:
- Anemia and iron deficiency are prevalent in children with CRD.
- Prophylactic iron supplementation is effective in preventing the decline of iron reserves.
- Early monitoring and treatment, or prophylactic supplementation, are recommended for children with CRD.
Introduction:
Children with chronic respiratory disease (CRD) are at increased risk of iron deficiency and anemia, which is under-diagnosed.
Aim:
To describe the iron (Fe) status in children with CRD and to evaluate the effects of its prophylactic indication.
Method:
Prospective study of children with CRD and adequate Fe intake in the diet. At baseline we measured hemogram, C-reactive protein and Fe profile. Subsequently, those with normal plasma hemoglobin (Hb) were not supplemented with Fe (Group A) and those with iron deficiency anemia or at risk of developing it (group B) were supplemented. We evaluated them 3 months later and, after supplementing all, at 4th month.
Results:
Of 40 patients, median 30 months old (0.5 to 178), 60% were male, 80% eutrophic. Ventilation or oxygen were required in 45%. Diagnoses: 50% Chronic Lung Damage, 17.5% airway diseases, 10% Bronchopulmonary Dysplasia, 7.5% Cystic Fibrosis and 13.5% other. At baseline 20% were anemic (mostly ferropenic) and 12.5% had an abnormal iron profile. At all, 25 children completed the study: in group A, serum ferritin decreased to 3(th) month (-22.9 ± 30) and incremented to 4(th)month (+12.8 ± 26) μg/L (p = 0.013), without difference in Hb. Group B had a rise in Hb (91 ± 12 to 102 ± 12% of the mean for age, p = 0.04).
Conclusion:
Anemia and ferropenia are frequent in children with CRD. Decrease of their iron reserves can be prevented if they are supplemented. We suggest monitoring properly and treating early or supplement them prophylactically.
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