[Anemia and iron deficiency in children with chronic respiratory diseases]

Salesa Barja1, Eduardo Capo, Lilian Briceño

  • 1Departamento de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile. sbarja@puc.cl

Insights

Iron deficiency and anemia are common in children with chronic respiratory disease (CRD). Prophylactic iron supplementation can prevent the depletion of iron reserves in these vulnerable children.

Area of Science:

  • Pediatric Pulmonology
  • Hematology
  • Nutritional Science

Background:

  • Children with chronic respiratory disease (CRD) face a higher risk of iron deficiency and anemia.
  • This condition is frequently under-diagnosed in this population.

Purpose of the Study:

  • To assess the iron status in pediatric patients diagnosed with CRD.
  • To evaluate the impact of prophylactic iron supplementation on iron status and related biomarkers.

Main Methods:

  • A prospective study involving children with CRD and adequate dietary iron intake.
  • Baseline measurements included hemogram, C-reactive protein, and iron profile.
  • Children were divided into two groups: one without iron supplementation and another receiving supplementation for iron deficiency anemia or at risk.

Main Results:

  • At baseline, 20% of children were anemic and 12.5% had abnormal iron profiles.
  • In the non-supplemented group, serum ferritin decreased over 3 months but recovered by 4 months.
  • The supplemented group showed a significant increase in hemoglobin levels.

Conclusions:

  • Anemia and iron deficiency are prevalent in children with CRD.
  • Prophylactic iron supplementation is effective in preventing the decline of iron reserves.
  • Early monitoring and treatment, or prophylactic supplementation, are recommended for children with CRD.
Abstract

Related Concept Videos

The Periodic Table and Organismal Elements00:57

The Periodic Table and Organismal Elements

OverviewElements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally-occurring, and fewer still are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.The Periodic Table Provides Information...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Factors Affecting Respiration01:24

Factors Affecting Respiration

Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...