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Protein microarrays: technological aspects, applications and intellectual property.
Noelia Dasilva1, Paula Díez, María González-González
1Centro de Investigación del Cáncer/IBMCC USAL/CSIC, IBSAL, Departamento de Medicina and Servicio General de Citometría, University of Salamanca, Salamanca 37007, Spain.
Recent Patents on Biotechnology
|July 16, 2013
Summary
Recent patents enhance proteomics technology for robust, sensitive protein detection. These advancements aim to improve disease biomarker identification, making it more reliable, biocompatible, and eco-friendly.
Area of Science:
- Proteomics and biotechnology
- Biomarker discovery and diagnostics
Background:
- Proteomics has advanced significantly due to technical innovations in recent years.
- Protein microarrays have improved, enabling robust, specific, sensitive, real-time, and high-throughput protein detection.
Purpose of the Study:
- To review recently approved patents addressing challenges in proteomics.
- To highlight innovations that overcome limitations in analyzing low-abundance proteins and complex samples.
Main Methods:
- Analysis of recent patent literature in proteomics.
- Focus on patents related to protein microarray design, surface functionalization, capture agents, and detection strategies.
Main Results:
- Patents are emerging to tackle existing problems in protein analysis.
- Innovations aim to improve the detection of low-abundance proteins and proteins in complex biological samples.
Conclusions:
- Patented advancements are expected to enable suitable and reliable identification of disease biomarkers.
- Future applications emphasize biocompatible and environmentally friendly diagnostic approaches.
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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
01:33Proteomics
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
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