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Related Experiment Video

Updated: May 9, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

DNA-programmed mesoscopic architecture.

Jonathan D Halverson1, Alexei V Tkachenko

  • 1Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, USA.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|July 16, 2013
PubMed
Summary
This summary is machine-generated.

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Researchers used DNA-functionalized nanoparticles (NPs) for programmed self-assembly into complex shapes. This method avoids slow kinetics and achieves high yields for diverse mesoscopic structures.

Area of Science:

  • Nanotechnology
  • Materials Science
  • Biophysics

Background:

  • Self-assembly of nanoparticles (NPs) is crucial for creating advanced materials.
  • Achieving programmed local morphology and complex shapes in mesoscopic structures remains a challenge.
  • Unwanted metastable configurations can impede self-assembly kinetics.

Purpose of the Study:

  • To investigate the self-assembly of directionally functionalized NPs into programmed mesoscopic structures.
  • To demonstrate a method for designing complex shapes with high yield.
  • To develop design strategies for controlled NP self-assembly.

Main Methods:

  • Utilizing NPs directionally functionalized with DNA as building blocks.
  • Employing numerical simulations to model and predict self-assembly outcomes.

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Last Updated: May 9, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
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Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Simple, Affordable, and Modular Patterning of Cells using DNA
08:59

Simple, Affordable, and Modular Patterning of Cells using DNA

Published on: February 24, 2021

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

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  • Analyzing the role of directional and selective interactions in preventing kinetic traps.

    • Main Results:

    • Successful self-assembly of various mesoscopic structures, including cubes, pyramids, and boxes.
    • Demonstrated the ability to create complex, large-scale models like the Empire State Building.
    • Achieved near-perfect yields for designed mesoscopic objects.

    Conclusions:

    • Directional DNA functionalization of NPs enables precise control over self-assembly.
    • The proposed method overcomes limitations of slow kinetics and metastable states.
    • Effective design strategies were identified for assembling diverse mesostructures with high fidelity.