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[Relationship between inflammation marker and all-cause and cardiovascular mortality in a prospective cohort study]
Julio A Carbayo Herencia1, Marta Simarro Rueda, Luis Miguel Artigao Ródenas
1Unidad de Lípidos, Capio Clínica Albacete, Albacete, España. jacarbayoh@telefonica.net
Insights
High fibrinogen levels predict increased mortality risk in men. This study found hyperfibrinogenemia (≥400mg/dl) independently predicts all-cause and cardiovascular mortality in men without prior cardiovascular events.
Area of Science:
- Cardiovascular Medicine
- Biomarkers
- Epidemiology
Context:
- Atherosclerosis is an inflammatory disease.
- Fibrinogen is a key inflammation marker.
- Mortality is a critical complication of atherosclerosis.
Purpose:
- To assess the association between fibrinogen levels and all-cause mortality.
- To investigate fibrinogen as a predictor of cardiovascular mortality.
- Study conducted on a general population sample in Albacete, Spain.
Summary:
- A prospective cohort study included 506 men without cardiovascular events.
- Fibrinogen levels were analyzed using Cox regression, adjusting for major cardiovascular risk factors.
- Hyperfibrinogenemia (≥400mg/dl) was associated with increased all-cause mortality (HR=1.85) and cardiovascular mortality (HR=2.69).
Impact:
- Fibrinogen is identified as an independent predictor of mortality in men.
- Findings highlight the prognostic value of fibrinogen in cardiovascular health.
- Results contribute to understanding atherosclerosis complications and risk stratification.
Introduction:
Inflammation is present in every stage of the atherosclerosis process, therefore, inflammation hallmarks such as the fibrinogen can be related to the complications in which it intervenes, mortality is one of them. The objective of this study is to assess the association of the fibrinogen with all-cause mortality in men from general population sample obtained by random sampling in the Spanish region of Albacete.
Methods:
A total of 506men without cardiovascular events with 10.6years (SD=2.3) of follow-up, volunteered to participate in a prospective cohort study. The assessment of the fibrinogen as a predictor variable has been calculated after adjusting it by age, hypertension, diabetes mellitus, obesity, total cholesterol, HDL-cholesterol/triglycerides ratio, and smoking habit applying a Cox regression model. The adjustment has been made by adding the fibrinogen to the model, as a qualitative variable (<400 and ≥400mg/dl).
Results:
The average age of the participants was 46.6years old (DE=16.8). After the adjustment, the hyperfibrinogenemia (≥400mg/dl) showed a hazard ratio (HR) for all-cause mortality of 1.85 (95%CI: 1.05-3.26) and for cardiovascular mortality HR=2.69 (95%CI: 1.09-6.63).
Conclusions:
In men without cardiovascular events of our study, fibrinogen was showed as an independent predictor of all-cause mortality and cardiovascular mortality.
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